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Deconstruction of cellular dynamics after treatment of volumetric muscle loss injury with extracellular matrix

ABSTRACT: Volumetric muscle loss (VML) is an acute loss of a critical volume of skeletal muscle that results in inflammation, fibrotic scarring in muscle tissue, and permanent muscle defects. The cellular and molecular processes that underlie fibrosis induced from VML injury need to be evaluated in larger animal models. Therefore, we used a canine model of VML alongisde treatment with an extracellular matrix (ECM) hydrogel. Treatment with the ECM hydrogel improved muscle regenerative responses and decreased proportions and spatial signatures of fibrotic and inflammatory cell populations.

ORGANISM(S): Canis lupus familiaris

PROVIDER: GSE266585 | GEO | 2024/06/01

REPOSITORIES: GEO

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Spatiotemporal mapping of immune and stem cell dysregulation after volumetric muscle loss

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