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Mitochondrial Dynamics Govern Whole-body Regeneration Through Stem Cell Pluripotency and Mitonuclear Balance [RNAi scRNA-seq]

ABSTRACT: To further identity the relationship between neoblast pluripotency and mitochondrial dynamics in cell lineage commitment,single-cell RNA sequencing was used to further analyze the compositions of mito low cells. To further identify the relationship between all different tissues cells and mito chondrial dynamics, snRNA-seq was used to further analyisis.

ORGANISM(S): Schmidtea mediterranea

PROVIDER: GSE266661 | GEO | 2024/11/07

REPOSITORIES: GEO

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Mitochondrial Dynamics Govern Whole-body Regeneration Through Stem Cell Pluripotency and Mitonuclear Balance [scRNA-seq]

Project description:To further identity the relationship between neoblast pluripotency and mitochondrial dynamics in cell lineage commitment,single-cell RNA sequencing was used to further analyze the compositions of mito low and mito high cells

2024-11-07 | GSE244069 | GEO

Mitochondrial Dynamics Govern Whole-body Regeneration Through Stem Cell Pluripotency and Mitonuclear Balance [bulk RNA-seq]

Project description:To investigate the mechanism of mitochondrial morphology in neoblast pluripotenc and whole body regeneration,the Bulk RNA-seq and single cell RNA-seq data were needed.

2024-11-07 | GSE244068 | GEO

Mitochondrial Dynamics Govern Whole-body Regeneration Through Stem Cell Pluripotency and Mitonuclear Balance

Project description:This SuperSeries is composed of the SubSeries listed below.

2024-11-07 | GSE244070 | GEO

Mitochondrial Dynamics Govern Whole-body Regeneration Through Stem Cell Pluripotency and Mitonuclear Balance

Project description:Mitochondrial Dynamics Govern Whole-body Regeneration Through Stem Cell Pluripotency and Mitonuclear Balance

| PRJNA1021189 | ENA

Mitochondrial Dynamics Govern Whole-body Regeneration Through Stem Cell Pluripotency and Mitonuclear Balance [scRNA-seq]

Project description:Mitochondrial Dynamics Govern Whole-body Regeneration Through Stem Cell Pluripotency and Mitonuclear Balance [scRNA-seq]

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Mitochondrial Dynamics Govern Whole-body Regeneration Through Stem Cell Pluripotency and Mitonuclear Balance [RNAi scRNA-seq]

Project description:Mitochondrial Dynamics Govern Whole-body Regeneration Through Stem Cell Pluripotency and Mitonuclear Balance [RNAi scRNA-seq]

| PRJNA1108219 | ENA

Mitochondrial Dynamics Govern Whole-body Regeneration Through Stem Cell Pluripotency and Mitonuclear Balance [bulk RNA-seq]

Project description:Mitochondrial Dynamics Govern Whole-body Regeneration Through Stem Cell Pluripotency and Mitonuclear Balance [bulk RNA-seq]

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The human mitochondrial translatome promotes mitonuclear balance

Project description:Oxidative phosphorylation (OXPHOS) complexes consist of nuclear- and mitochondrial- encoded subunits, forcing cross-compartment synchronization of gene expression to achieve mitonuclear balance. To characterize how human cells coordinate OXPHOS gene expression, we establish a mitoribosome profiling approach that resolves features of the mitochondrial translatome, including the synthesis of a four amino acid mitopeptide. Strikingly, average mitochondrial and cytoplasmic synthesis rates correspond precisely across OXPHOS complexes. Coordinated mitochondrial and cytosolic synthesis does not require rapid feedback between the two translation systems. By contrast, we find that the Leigh syndrome gene, LRPPRC, maintains correlated mitochondrial and cytosolic translatomes. Our results lead to a model of human mitonuclear balance that requires tightly balanced cross-compartment protein synthesis, representing a vulnerability for cellular proteostasis.

2021-05-30 | GSE173283 | GEO

Parallel evolution of genes controlling mitonuclear balance in short-lived annual fishes.

Project description:The current molecular understanding of the aging process derives almost exclusively from the study of random or targeted single-gene mutations in highly inbred laboratory species, mostly invertebrates. Little information is available as to the genetic mechanisms responsible for natural lifespan variation and the evolution of lifespan, especially in vertebrates. Here, we investigated the pattern of positive selection in annual (i.e., short-lived) and nonannual (i.e., longer-lived) African killifishes to identify a genomic substrate for evolution of annual life history (and reduced lifespan). We identified genes under positive selection in all steps of mitochondrial biogenesis: mitochondrial (mt) DNA replication, transcription from mt promoters, processing and stabilization of mt RNAs, mt translation, assembly of respiratory chain complexes, and electron transport chain. Signs of paralleled evolution (i.e., evolution in more than one branch of Nothobranchius phylogeny) are observed in four out of five steps. Moreover, some genes under positive selection in Nothobranchius are under positive selection also in long-lived mammals such as bats and mole-rats. Complexes of the respiratory chain are formed in a coordinates multistep process where nuclearly and mitochondrially encoded components are assembled and inserted into the inner mitochondrial membrane. The coordination of this process is named mitonuclear balance, and experimental manipulations of mitonuclear balance can increase longevity of laboratory species. Our data strongly indicate that these genes are also casually linked to evolution lifespan in vertebrates.

| S-EPMC5418189 | biostudies-literature

Regulators of mitonuclear balance link mitochondrial metabolism to mtDNA expression

Project description:Mitochondrial oxidative phosphorylation (OXPHOS) complexes are assembled from proteins encoded by both nuclear and mitochondrial DNA. These dual-origin enzymes pose a complex gene regulatory challenge for cells requiring coordinated gene expression across organelles. To identify genes involved in dual-origin protein complex synthesis, we performed FACS-based genome-wide screens analyzing mutant cells with unbalanced levels of mitochondrial- and nuclear-encoded subunits of Complex IV. We identified novel genes involved in OXPHOS biogenesis, including two uncharacterized genes: PREPL and NME6. We found that PREPL specifically impacts Complex IV biogenesis by acting at the intersection of mitochondrial lipid metabolism and protein synthesis, while NME6, an uncharacterized nucleoside diphosphate kinase (NDPK), controls OXPHOS biogenesis through multiple mechanisms reliant on its NDPK domain. First, NME6 forms a complex with RCC1L, which together perform NDPK activity to maintain local mitochondrial pyrimidine triphosphate levels essential for mitochondrial RNA abundance. Second, NME6 modulates the activity of mitoribosome regulatory complexes, altering mitoribosome assembly and mitochondrial RNA pseudouridylation. Taken together, we propose that NME6 acts as a link between compartmentalized mitochondrial metabolites and mitochondrial gene expression.

2023-08-23 | PXD044812 | Pride

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