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Spermine-induced DNA methylation change in human macrophages

ABSTRACT: Polyamines, crucial molecules involved in cell proliferation and growth, play a pivotal role in cancer development and progression. Within the tumor microenvironment, macrophages, key components of the immune system, exhibit a complex relationship with polyamines. Evidence suggests that polyamines can modulate macrophage polarization, influencing their functional phenotypes. Here, we detected the gene DNA methylation changes in spermine-stimulated human macrophages isolated from PBMCs and TAMs.

ORGANISM(S): Paslahepevirus balayani Mycobacterium canetti Yersinia pestis Streptobacillus moniliformis Escherichia coli O157:H7 Mycobacterium tuberculosis variant bovis Francisella tularensis subsp. novicida Mycobacterium avium Bartonella henselae Rickettsia typhi Mammarenavirus choriomeningitidis Toxoplasma gondii Orthohantavirus seoulense Francisella tularensis subsp. holarctica Yersinia enterocolitica Bartonella quintana Homo sapiens Campylobacter jejuni Mycobacterium avium subsp. paratuberculosis Leptospira interrogans Francisella tularensis subsp. mediasiatica Orthohantavirus puumalaense Mycobacterium tuberculosis Salmonella enterica subsp. enterica serovar Typhimurium Francisella tularensis subsp. tularensis Mycobacterium tuberculosis variant microti Rickettsia prowazekii Staphylococcus aureus Cowpox virus Yersinia pseudotuberculosis

PROVIDER: GSE267014 | GEO | 2024/05/13

REPOSITORIES: GEO

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Spermine-induced gene expression change in human macrophages

Project description:Polyamines, crucial molecules involved in cell proliferation and growth, play a pivotal role in cancer development and progression. Within the tumor microenvironment, macrophages, key components of the immune system, exhibit a complex relationship with polyamines. Evidence suggests that polyamines can modulate macrophage polarization, influencing their functional phenotypes. Here, we detected the gene expression changes in spermine-stimulated human macrophages isolated from PBMCs.

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