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RNA profiling of CSF resident macrophages and monocyte-macrophages from leptomeningeal metastasis mice

ABSTRACT: We investigated the functional effect of dura-derived leptomeningeal matastasis (LM)-associated macrophages (dLAMs) on the cerebrospinal fluid (CSF) niche during LM outgrowth. Using lung cancer leptomeningeal metastasis models of Cx3cr1CreER:mTmG mice with tamoxifen administration, we achieved dLAMs and monocyte-macrophages via fluorescence-activated cell sorting (FACS). Then we performed bulk RNAseq analysis for these two cell populations.

ORGANISM(S): Mus musculus

PROVIDER: GSE267325 | GEO | 2024/07/24

REPOSITORIES: GEO

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