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Differential contributions of fetal mononuclear phagocytes to Zika neuroinvasion versus neuroprotection during congenital infection

ABSTRACT: Fetal microglia had a protective role once differentiated in the brain, as their absence increased infection burden and neuronal death. Conversely, monocyte depletion reduced non-productive neuroinflammation. We used Single-cell RNA sequencing (scRNA-seq) to identify transcriptional profiles linked to the protective versus detrimental contributions of mononuclear phagocyte subsets during ZIKV infection in the fetal brain.

ORGANISM(S): Mus musculus

PROVIDER: GSE267677 | GEO | 2024/11/11

REPOSITORIES: GEO

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