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Exploring the role of TAGLN in the pathogenesis of pathological scarring

ABSTRACT: Pathological scarring is a fibroproliferative disorder characterised by abnormal fibroblast function and excessive deposition of extracellular matrix. In this study, based on the results of preliminary single-cell sequencing, we identified an enriched fibroblast subpopulation in keloids, which highly expresses TAGLN. In this study, we investigated the roles of TAGLN in the pathogenesis of pathological scars, respectively. And functional assays revealed that downregulation of TAGLN inhibited the motility activity and secretory functions of pathological scar fibroblasts, including invasion, migration, contraction and collagen secretion. We identified downstream targets of TAGLN by RNA-seq results analysis and further validation in. This study provides new perspectives for understanding pathological scarring and possible targets for clinical treatment.

ORGANISM(S): Homo sapiens

PROVIDER: GSE268002 | GEO | 2024/06/01

REPOSITORIES: GEO

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Exploring the role of TAGLN in the pathogenesis of pathological scarring

Project description:Exploring the role of TAGLN in the pathogenesis of pathological scarring

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