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Exploring the role of TAGLN and HTRA1 in the pathogenesis of pathological scarring

ABSTRACT: Pathological scarring is a fibroproliferative disorder characterised by abnormal fibroblast function and excessive deposition of extracellular matrix. In this study, based on the results of preliminary single-cell sequencing, we identified an enriched fibroblast subpopulation in keloids, which highly expresses TAGLN and HTRA1. In this study, we investigated the roles of TAGLN and HTRA1 in the pathogenesis of pathological scars, respectively. And functional assays revealed that downregulation of TAGLN and HTRA1 inhibited the motility activity and secretory functions of pathological scar fibroblasts, including invasion, migration, contraction and collagen secretion. We identified downstream targets of TAGLN and HTRA1 by RNA-seq results analysis and further validation in. This study provides new perspectives for understanding pathological scarring and possible targets for clinical treatment.

ORGANISM(S): Homo sapiens

PROVIDER: GSE268002 | GEO | 2024/06/01

REPOSITORIES: GEO

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Human Scarring Project

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