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The underlying mechanism of SCNAs-induced lncRNA LOC101927668 overexpressoin facilitating colorectal cancer progression

ABSTRACT: Somatic copy number alterations (SCNAs) are pivotal in cancer progression and patient prognosis. Dysregulated long non-coding RNAs (lncRNAs), modulated by SCNAs, significantly impact tumorigenesis, including colorectal cancer (CRC). Nonetheless, the functional significance of lncRNAs induced by SCNAs in CRC remains largely unexplored. In this study, we elucidate that the overexpression of LOC101927668, driven by SCNAs, facilitates CRC proliferation and metastasis by recruiting hnRNPD, thus perturbing the RBM47/P53/P21 signaling pathway.

ORGANISM(S): Homo sapiens

PROVIDER: GSE268122 | GEO | 2024/10/15

REPOSITORIES: GEO

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