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Effect of 4-octyl itaconate on gene expression of dendritic cells

ABSTRACT: Here, we report that macrophage-derived itaconate exerts a significant suppressive effect on dendritic cell (DC) function. To delve deeper into the impact of itaconate on DCs, we treated bone marrow-derived dendritic cells with 4-OI, a derivative of itaconate, and conducted RNA-seq analysis. Gene-set enrichment analysis (GSEA) of 4-OI-treated DCs showed a general downregulation of innate immunity and immune-response pathways.

ORGANISM(S): Mus musculus

PROVIDER: GSE268402 | GEO | 2024/06/30

REPOSITORIES: GEO

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