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Effect of overexpression or knockdown of trophoblast-related gene GPRC5A on migration and invasion of esophageal squamous cell carcinoma

ABSTRACT: Emerging evidence suggests that cancer cells possess the capacity to disseminate at early stages, preceding the development of conventional macro-metastases. Nevertheless, the mechanisms governing the seeding and transition of these early disseminated cancer cells (DCCs) into metastatic tumors remain largely unknown. Strikingly, we showed that GPRC5A-overexpressing ESCC cells exhibited an enhanced capacity to effectively implant, survive, and persist, ultimately giving rise to macro-metastases in the lungs in vivo. Therefore, we try to find the potential mechanism of GPRC5A-involved tumor implantation mechanism via overexpressing or silencing GPRC5A in vitro.

ORGANISM(S): Homo sapiens

PROVIDER: GSE268424 | GEO | 2024/10/24

REPOSITORIES: GEO

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