Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Adrenal gland macrophages regulate glucocorticoid production through Trem2 and TGFβ [scRNA-seq]

ABSTRACT: To elucidate how adrenal gland immune cells response to acute or chronic stressors

ORGANISM(S): Mus musculus

PROVIDER: GSE268521 | GEO | 2024/06/03

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

Adrenal gland macrophages regulate glucocorticoid production through Trem2 and TGFβ [Bulk RNA-seq]

Project description:To elucidate how the influence of Trem2-deficiency on adrenal gland gene expression during a model of chronic atherosclerosis

2024-06-03 | GSE268522 | GEO

Adrenal gland macrophages regulate glucocorticoid production through Trem2 and TGFβ [scRNA-seq]

Project description:Adrenal gland macrophages regulate glucocorticoid production through Trem2 and TGFβ [scRNA-seq]

| PRJNA1117498 | ENA

Adrenal gland macrophages regulate glucocorticoid production through Trem2 and TGFβ [Bulk RNA-seq]

Project description:Adrenal gland macrophages regulate glucocorticoid production through Trem2 and TGFβ [Bulk RNA-seq]

| PRJNA1117497 | ENA

microRNA counts from adrenal gland (ENCSR895SFC)

Project description:microRNA counts from adrenal gland (ENCSR895SFC)

| PRJNA909651 | ENA

microRNA counts from adrenal gland (ENCSR381ADE)

Project description:microRNA counts from adrenal gland (ENCSR381ADE)

| PRJNA909693 | ENA

WGBS from adrenal gland (ENCSR042LOG)

Project description:WGBS sequencing from adrenal gland tissue For data usage terms and conditions, please refer to http://www.genome.gov/27528022 and http://www.genome.gov/Pages/Research/ENCODE/ENCODE_Data_Use_Policy_for_External_Users_03-07-14.pdf

2019-03-03 | GSE127282 | GEO

WGBS from adrenal gland (ENCSR741FVM)

2019-03-03 | GSE127311 | GEO

eCLIP from adrenal gland (ENCSR096YAP)

Project description:eCLIP control experiment on adrenal gland against HNRNPU For data usage terms and conditions, please refer to http://www.genome.gov/27528022 and http://www.genome.gov/Pages/Research/ENCODE/ENCODE_Data_Use_Policy_for_External_Users_03-07-14.pdf

2017-01-03 | GSE91477 | GEO

eCLIP from adrenal gland (ENCSR634MFO)

Project description:eCLIP experiment on adrenal gland from the GTEx collection against DGCR8 For data usage terms and conditions, please refer to http://www.genome.gov/27528022 and http://www.genome.gov/Pages/Research/ENCODE/ENCODE_Data_Use_Policy_for_External_Users_03-07-14.pdf

2021-06-15 | GSE177629 | GEO

Unravelling the sex-specific diversity and functions of adrenal gland macrophages (RNA-Seq).

Project description:Despite the ubiquitous function of macrophages across the body, the diversity, origin, and function of adrenal gland macrophages remain largely unknown. We defined the heterogeneity of adrenal gland immune cells using single-cell RNA sequencing and used genetic models to explore the developmental mechanisms yielding to macrophage diversity. We defined populations of monocyte-derived and embryonically seeded adrenal gland macrophages and identified a female-specific subset with low MHC-II expression. In adulthood, monocyte recruitment dominated adrenal gland macrophage maintenance in female mice, while self-proliferation was more important in males. Adrenal gland macrophage sub-tissular distribution followed a sex-dimorphic pattern, with MHC-IIlow macrophages located at the border between the cortex and the medulla. Macrophage sex dimorphism depended on the presence of the cortical Xzone. Forcing X-zone maintenance in males, or its degradation in females, directly impacted the presence of MHC-IIlow macrophages. Adrenal gland macrophage depletion resulted in altered tissue homeostasis, modulated lipid- metabolism and decreased local aldosterone production during stress exposure. Overall, these data explain the heterogeneity of adrenal gland macrophages and point toward sexrestricted distribution and functions of these cells.

2022-05-23 | GSE203096 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data