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BMPR1A-mediated BMP signalling ensures correct mitosis-to-meiosis transition in mouse fetal ovarian germ cells, in vivo

ABSTRACT: A successful mitosis-to-meiosis transition in germ cells is essential for fertility in sexually reproducing organisms. In mice and humans, it is established that STRA8 expression is critical for meiotic onset in both sexes. Here we show that BMP signalling is also essential, not for STRA8 induction but for correct meiotic progression in mouse fetal ovarian germ cells. Germ cell-specific deletion of Bmpr1a caused aberrant expression of meiotic, pluripotency, and cell cycle genes in E14.5 mouse fetal ovaries. Our results verify a role for BMP signalling in instructing germ cell meiosis in female mice in vivo, and shed light on the regulatory mechanisms underlying fetal germ cell development.

ORGANISM(S): Mus musculus

PROVIDER: GSE268565 | GEO | 2025/01/16

REPOSITORIES: GEO

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BMPR1A-mediated BMP signalling ensures correct mitosis-to-meiosis transition in mouse fetal ovarian germ cells, in vivo

Project description:BMPR1A-mediated BMP signalling ensures correct mitosis-to-meiosis transition in mouse fetal ovarian germ cells, in vivo

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