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Genes associated with mitogen-activated protein kinase activity in pancreatic cancer cells

ABSTRACT: We performed a transcriptome analysis to determine what genes were altered in expression when U0126, MAP2K inhibitor, was administered to cells of human pancreatic cancer cell lines. Five genes including ETV5, ETV4, COL13A1, HIST1H4L/H4C13, and WDR62 were found to be particularly downregulated by the inhibition of MAPK pathway, meaning that these genes were preferentially upregulated by the active MAPK. The expression of ETV5 was most modulated, suggesting that ETV5 is strongly associated with the MAPK activity and may play a role in human pancreatic cancer.

ORGANISM(S): Homo sapiens

PROVIDER: GSE268817 | GEO | 2024/06/05

REPOSITORIES: GEO

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