Interaction of solute carrier family 39 member 1 and dynamin related protein 1 to facilitate development of hepatocellular carcinoma by impairing mitochondrial quality control
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ABSTRACT: In this study, HCC samples from 12 non-relapsed and 15 relapsed HCC patients after surgically resection, were collected for RNA sequencing. Liver-specific SLC39A1 knockout mice (SLC39A1lko) were generated by crossing Alb-Cre mice and SLC39A1flox/flox mice. Liver samples from mice were analyzed for inflammation, fibrosis and proliferation. Mitochondrial dynamics, autophagy, ROS and mitochondrial membrane potential (MMP), were detected. Co-immunoprecipitation and molecular docking were used to identify protein interactions. Targeting 1-28 peptide of SLC39A1 was designed.
ORGANISM(S): Homo sapiens
PROVIDER: GSE268875 | GEO | 2024/06/10
REPOSITORIES: GEO
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