Transcriptomics

Dataset Information

0

Effect of FTO-KD or FTO-OE on gene expression in GH3 cell line


ABSTRACT: Growth hormone-secreting pituitary adenomas account for approximately 10% of endocrine pituitary tumors and are pathologically classified into densely granulated adenomas (DGGH) and sparsely granulated adenomas (SGGH). m6A has been reported to play an important role in tumorigenesis and development, but its potential role in the pathogenesis of these two subtypes has not yet been thoroughly investigated. Consequently, we performed MeRIP-seq analysis of pituitary adenomas and the GH3 cell line. We observed that the expression of FTO was significantly increased in SGGH, leading to a reduction in m6A modification and a disruption of desmosome organization.

ORGANISM(S): Rattus norvegicus

PROVIDER: GSE269044 | GEO | 2024/09/25

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2024-09-25 | GSE269321 | GEO
2024-01-24 | GSE246645 | GEO
2024-04-28 | GSE264621 | GEO
2022-06-19 | GSE202934 | GEO
2024-03-04 | GSE260487 | GEO
2023-09-25 | GSE226764 | GEO
2013-06-15 | E-GEOD-47216 | biostudies-arrayexpress
2006-02-14 | GSE4237 | GEO
2008-06-12 | E-GEOD-4237 | biostudies-arrayexpress
2016-02-06 | GSE77517 | GEO