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ScRNA-Seq reveals anti-fibrotic mechanisms of TRPC6 inhibition [scRNA-seq]

ABSTRACT: Inhibition of transient receptor potential canonical 6 channels (TRPC6) alleviates tubular injury and renal fibrosis induced by unilateral ureteral obstruction (UUO).However, the exact renoprotective mechanisms are unknown. In this study, we utilized single-cell RNA sequencing (scRNA-Seq) to define the cellular and transcriptional landscape associated with renoprotection through in vivo TRPC6 inhibition, specifically using SH045 (larixyl N-methylcarbamate), in the UUO model.

ORGANISM(S): Mus musculus

PROVIDER: GSE269062 | GEO | 2024/06/08

REPOSITORIES: GEO

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scRNA-Seq reveals anti-fibrotic mechanisms of TRPC6 inhibition [Spatial Transcriptomics]

Project description:Inhibition of transient receptor potential canonical 6 channels (TRPC6) alleviates tubular injury and renal fibrosis induced by unilateral ureteral obstruction (UUO).However, the exact renoprotective mechanisms are unknown. In this study, we utilized single-cell RNA sequencing (scRNA-Seq) to define the cellular and transcriptional landscape associated with renoprotection through in vivo TRPC6 inhibition, specifically using SH045 (larixyl N-methylcarbamate), in the UUO model.

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scRNA-Seq reveals anti-fibrotic mechanisms of TRPC6 inhibition [scRNA-seq]

Project description:scRNA-Seq reveals anti-fibrotic mechanisms of TRPC6 inhibition [scRNA-seq]

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