Transcriptomics

Dataset Information

0

Regulation of intracellular pH by SLC4A7 tunes mTORC1 function to promote plasma cell differentiation


ABSTRACT: B cells differentiate into antibody-producing plasma cells, which are critical for humoral immunity, autoimmunity, and vaccine responses. Despite the importance of environmental stressors on regulating humoral immune responses, the influence of pH on PC differentiation has not been described. Here, we identified SLC4A7, a sodium/bicarbonate cotransporter, as a selective regulator of PC differentiation. SLC4A7 deletion impaired the formation of PCs and humoral immunity to influenza A virus infection in mice. Mechanistically, we find that SLC4A7 prevents acidification of intracellular pH and thus maintains lysosomal function and mTORC1 activity. Loss of SLC4A7 suppresses PC differentiation under conditions of extracellular acidosis in vitro and in a mouse model of metabolic acidosis. Here we reveal a novel relationship between the regulation of intracellular pH by SLC4A7 and mTORC1-dependent PC differentiation and humoral immunity.

ORGANISM(S): Mus musculus

PROVIDER: GSE269509 | GEO | 2024/06/14

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2019-07-15 | PXD014034 | Pride
2018-04-12 | GSE113016 | GEO
2022-01-12 | PXD024529 | panorama
2024-11-05 | GSE237560 | GEO
| PRJNA1122164 | ENA
2016-07-22 | E-GEOD-75007 | biostudies-arrayexpress
2017-08-04 | GSE85555 | GEO
2016-07-22 | GSE75007 | GEO
2013-04-25 | GSE40060 | GEO
2024-06-13 | GSE269681 | GEO