Transcriptomics

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Genetic diversity accelerates canine distemper virus adaptation to ferrets


ABSTRACT: RNA viruses adapt rapidly to new host environments by generating highly diverse genome sets, so-called “quasispecies”. Minor genetic variants promote their rapid adaptation allowing for emergence of drug-resistance or immune-escape mutants. Understanding these adaptation processes is highly relevant to assess the risk of cross-species transmission, and safety and efficacy of vaccines and antivirals. We hypothesized that genetic memory within a viral genome population facilitates rapid adaptation.

ORGANISM(S): Mustela putorius furo Chlorocebus sabaeus canine distemper virus

PROVIDER: GSE270448 | GEO | 2024/06/21

REPOSITORIES: GEO

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