Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Cut&Run analysis for transcription factors in MOLT-4 cells

ABSTRACT: Cut&Run analysis was performed in MOLT-4 cells to analyze the DNA bindings of BRD7, BRD9, DPF2 and GLTSCR1 on basal level.

ORGANISM(S): Homo sapiens

PROVIDER: GSE270462 | GEO | 2024/07/02

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

Cut&Run analysis for transcription factors in MOLT-4 cells

Project description:Cut&Run analysis was performed in MOLT-4 cells to analyze the level of H3K27ac and DNA bindings of SMARCA4 and RUNX1 after DMSO or BRM014 treatment.

2024-07-02 | GSE249318 | GEO

Cut&Run analysis for transcription factors in MOLT-4 cells.

Project description:Cut&Run analysis was performed in MOLT-4 cells to analyze the basal level of H3K4me3 and DNA binding of RUNX1 and SMARCA4.

2024-07-02 | GSE230592 | GEO

Cut&Run analysis for transcription factors in MOLT-4 cells.

Project description:Cut&Run analysis for transcription factors in MOLT-4 cells.

| PRJNA961808 | ENA

Cut&Run analysis for transcription factors in MOLT-4 cells

Project description:Cut&Run analysis for transcription factors in MOLT-4 cells

| PRJNA1048514 | ENA

Cut&Run analysis for transcription factors in MOLT-4 cells

Project description:Cut&Run analysis for transcription factors in MOLT-4 cells

| PRJNA1126673 | ENA

Cut&Run analysis for transcription factors in TAL1-FKBP12 Jurkat cells

Project description:Cut&Run analysis was performed in TAL1-FKBP12 Jurkat cells to analyze DNA bindings of GATA3 and RUNX1 after DMSO or dTAG-13 treatment.

2023-11-20 | GSE225936 | GEO

Cut&Run analysis for transcription factors in DND-41 cells

Project description:Cut&Run analysis was performed in DND-41 cells to analyze the basal level of H3K27ac and DNA bindings of BRG1 and RUNX1 after DMSO or ACBI-1 treatment.

2024-07-02 | GSE230593 | GEO

Cut & Run-seq analysis for transcription factors overexpression in GI-MEN cells

Project description:Cut & Run analysis was performed in an neuroblastoma cell line to analyze DNA bindings of ASCL1-tag-HA in GI-MEN ASCL1-tag-HA cells and GI-MEN ASCL1-tag-HA+4TFs cells; analyze DNA bindings of MYCN, PHOX2B and H3K27ac in, GI-MEN 4TFs cells, and GI-MEN ASCL1-tag-HA+4TFs cells.

2023-11-21 | GSE214793 | GEO

BRD9-containing non-canonical BAF chromatin remodeling complex acts as a barrier to somatic cell reprogramming (ATAC-Seq)

Project description:Epigenetic reprogramming requires extensive remodeling of chromatin landscapes to silence gene expression programs which sustain cell identity. ATP-dependent chromatin-remodeling complexes are important regulators of chromatin structure and gene expression; however, the role of Bromodomain containing protein 9 (BRD9) and the associated ncBAF (non-canonical BRG1-associated factors) complex in somatic cell reprogramming remains unknown. Here, we show that inhibition and acute degradation of BRD9 increases the efficiency by which induced pluripotent stem cells (iPSCs) can be generated from human fibroblasts. Genetic suppression of BRD9 as well as ncBAF complex subunit GLTSCR1, but not the closely related BRD7, phenocopied this effect. CRISRP/Cas9-mediated knockout of BRD9 demonstrated that it is dispensable for establishment and maintenance of human pluripotency. Mechanistically, BRD9 inhibition facilitates reprogramming by downregulating somatic cell type-specific genes and decreasing chromatin accessibility at somatic enhancers. Collectively, these results establish BRD9 as an important safeguarding factor for somatic cell identity whose inhibition lowers barriers to reprogramming.

2021-06-15 | GSE161639 | GEO