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Polyploid cancer cells reveal signatures of chemotherapy relapse [scDNA-seq]

ABSTRACT: Treatment of PC3 and MDA-MB-231 cell lines with sublethal doses of docetaxel or cisplatin in vitro resulted in induction of polyploid cancer cells. Single cell copy number profiling was conducted to understand resistance of polyploid cancer cells to chemotherapy.

ORGANISM(S): Homo sapiens

PROVIDER: GSE270567 | GEO | 2024/09/13

REPOSITORIES: GEO

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Polyploid cancer cells reveal signatures of chemotherapy relapse [scRNA-seq]

Project description:Treatment of PC3 and MDA-MB-231 cell lines with sublethal doses of docetaxel or cisplatin in vitro resulted in induction of polyploid cancer cells. Single cell copy RNA-sequencing was conducted to understand resistance of polyploid cancer cells to chemotherapy.

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Polyploid cancer cells reveal signatures of chemotherapy relapse [scDNA-seq]

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Silenced LINC01963 enhanced the chemosensitivity of prostate cancer cells to docetaxel by sponging miR-216b-5p to inhibit TrkB protein level

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