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Targeting CAFs-mediated Stromal Signaling Overcomes Stemness in a Patient-Derived Organotypic Colorectal Tumor Model

ABSTRACT: The goal of this experiment is to understand why co-culturing colon cancer cells with carcinoma associated fibroblasts (CAFs) causes the colon cancer cells to develop chemo-resistance. We cultured a patient-derived colon cancer cell model derived from conditional reprogramming with or without carcinoma-associated fibroblasts. Before sequencing, the co-cultured cells were purified using EpCAM immuno-magnetic beads to isolate cancer cells.

ORGANISM(S): Homo sapiens

PROVIDER: GSE270613 | GEO | 2025/02/19

REPOSITORIES: GEO

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