Transcriptomics

Dataset Information

0

LncRNA expression profile is associated with neoadjuvant chemotherapy resistance in luminal B breast cancer


ABSTRACT: Purpose: Identified the expression profile of lncRNAs associated to neoadjuvant chemotherapy response in 47 luminal B tumors of locally advanced breast cancer patients Methods: We implemented the transcriptomic analysis from 47 luminal B breast cancer samples by paired-end RNA-Seq, as a case-control study (responders vs nonresponders group). Differential expression analysis for lncRNA and mRNA were made to identify lncRNA as predictive biomarkers. Results: We identified a signature of lncRNAs associated with nonresponders group. Additionally, we identified the pathways were differentially expressed lncRNA and mRNA are associated in neoadjuvant chemotherapy response. Additionally, we proposed the clinical application of lncRNA GATA3-AS1 as a predictive biomarker to neoadjuvant chemotherapy response in luminal B breast cancer patients detected by RNA-ISH. Conclusion: we propose the clinical utility of lncRNA GATA3-AS1 detected by RNA-ISH to identify luminal B breast cancer patients that will not respond to neoadjuvant chemotherapy.

ORGANISM(S): Homo sapiens

PROVIDER: GSE270967 | GEO | 2024/08/27

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2021-07-12 | GSE159448 | GEO
2023-01-01 | GSE216413 | GEO
2013-01-15 | GSE43502 | GEO
2020-12-12 | GSE123828 | GEO
2013-01-15 | E-GEOD-43502 | biostudies-arrayexpress
2021-11-13 | GSE188743 | GEO
| PRJNA668985 | ENA
2019-01-31 | GSE106360 | GEO
2024-07-16 | GSE221061 | GEO
2024-07-16 | GSE221060 | GEO