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Quantification of induced RNA mutation by nucleoside analogs in the repRNA-v4 EGFP region

ABSTRACT: REPLACE was engineered from an orthogonal alphaviral RNA replication system. It generates a large, continuously diversified library of replicative RNAs through a replicase-limited mode of replication and inducible mutagenesis. We analyzed the variation of RNA mutations induced by two nucleoside analogues over time and at different concentrations. This data was used to guide the construction of RNA mutant libraries.

ORGANISM(S): Mesocricetus auratus

PROVIDER: GSE271881 | GEO | 2024/09/30

REPOSITORIES: GEO

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