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Role of growth differentiation factor 15 in mouse adipose tissue homeostasis

ABSTRACT: Recent research has identified growth differentiation factor 15 (GDF15) as a crucial factor in various physiological and pathological processes, particularly in energy balance regulation. We here investigated the role of GDF15 in adipose tissue physiology and metabolism by performing an RNA-Seq analysis of subcutaneous adipose tissue (sWAT) of 20 week old male and female Gdf15-KO mice compared to their WT littermates. Our study revealed a broad downregulation of genes involved in lipid metabolism and furthermore, it uncovered sex-specific effects, with females being more affected by GDF15 loss than males. These insights enhance our understanding of GDF15's functions in adipose tissue physiology and underscore its potential as a therapeutic target for metabolic disorders.

ORGANISM(S): Mus musculus

PROVIDER: GSE272291 | GEO | 2024/11/13

REPOSITORIES: GEO

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