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Various forms of calorie restriction, but not a nonrestricted low-fat diet, reverse obesity-associated tumor growth and lung metastasis in a mouse model of triple-negative breast cancer (microarray)

ABSTRACT: lean control, obese, and formerly obese C57BL6N mice which underwent weight loss via low-fat diet or various forms of calory restriction were injected with E0771 cells and tumor growth was monitored

ORGANISM(S): Mus musculus

PROVIDER: GSE272329 | GEO | 2025/02/04

REPOSITORIES: GEO

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Various forms of calorie restriction, but not a nonrestricted low-fat diet, reverse obesity-associated tumor growth and lung metastasis in a mouse model of triple-negative breast cancer-RNAseq

Project description:lean control, obese, and formerly obese C57BL6N mice which underwent weight loss via low-fat diet or various forms of calory restriction were injected with E0771 cells and tumor growth was monitored

2022-05-12 | GSE202330 | GEO

Various forms of calorie restriction, but not a nonrestricted low-fat diet, reverse obesity-associated tumor growth and lung metastasis in a mouse model of triple-negative breast cancer-RRBS

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Calorie Restriction Outperforms Bariatric Surgery in Reversing Obesity-Driven Tumor Progression in a Mouse Model of Triple Negative Breast Cancer-Study2_tumor

Project description:lean control, obese, and formerly obese C57BL6N mice which underwent weight loss via vertical sleeve gastrectomy or calorie restriction were injected with E0771 cells and tumor growth was monitored

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Calorie Restriction Outperforms Bariatric Surgery in Reversing Obesity-Driven Tumor Progression in a Mouse Model of Triple Negative Breast Cancer-RNAseq

Project description:lean control, obese, and formerly obese C57BL6N mice which underwent weight loss via low-fat diet or verticle sleeve gastrectomy were injected with E0771 cells and tumor growth was monitored

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Calorie Restriction Outperforms Bariatric Surgery in Reversing Obesity-Driven Tumor Progression in a Mouse Model of Triple Negative Breast Cancer-Study1_tumor

Project description:lean control, obese, and formerly obese C57BL6N mice which underwent weight loss via vertical sleeve gastrectomy or low fat diet were injected with E0771 cells and tumor growth was monitored

2023-09-12 | GSE230470 | GEO

Calorie Restriction Outperforms Bariatric Surgery in Reversing Obesity-Driven Tumor Progression in a Mouse Model of Triple Negative Breast Cancer-RRBS

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Age and obesity associated immune dysfunction mammary tumor growth

Project description:lean control, obese (DIO), aged 6 (young) or 18months (Aged) C57BL6N mice which underwent weight loss via intermittent calory restriction (ICR) or not (ad lib) were injected with E0771 cells and tumor growth was monitored

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Project description:Adipose tissue stromal cells from lean, obese, and formerly obese mice

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Gene expression profiling of adipocyte and stromal vascular cells from adipose tissue in lean, obese and formerly obese mice

Project description:To investigate the transcriptional profiles of adipocytes and stromal vascular cells from mouse visceral adipose tissue(vWAT) in lean (Low fat diet, LFD fed), obese (high fat diet, HFD fed) and formerly obese (diet switch (SW) from 9 weeks HFD, to 3 weeks LFD) to induce weight loss.

2022-08-04 | GSE210014 | GEO

Calorie restriction can reverse, as well as prevent, aging cardiomyopathy.

Project description:Calorie restriction (CR) is the most widely studied intervention protecting from the adverse effects of aging. Almost all prior studies have examined the effects of CR initiated in young animals. Studies examining the effects of CR on development of aging cardiomyopathy found only partial prevention. The major goal of this study was to determine whether CR initiated after aging cardiomyopathy developed could reverse the cardiomyopathy. Aging cardiomyopathy in 2-year-old mice was characterized by reduced left ventricular (LV) function, cardiac hypertrophy, and increased cardiac apoptosis and fibrosis. When short-term (2 months) CR was initiated after aging cardiomyopathy developed in 20-month-old mice, the decrease in cardiac function, and increases in LV weight, myocardial fibrosis and apoptosis were reversed, such that the aging hearts in these mice were indistinguishable from those of young mice or mice where CR was initiated in young mice. If apoptosis was the mechanism for protecting against aging cardiomyopathy, then total myocyte numbers should have reverted to normal with CR, but did not. However, the alterations in cytoskeletal proteins, which contribute to aging cardiomyopathy, were no longer observed with CR. This is the first study to demonstrate complete prevention of aging cardiomyopathy by CR and, more importantly, that instituting this intervention even later in life can rapidly correct aging cardiomyopathy, which could have important therapeutic implications.

| S-EPMC3825004 | biostudies-literature

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