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Endometriosis induced menstrual cycle dependent and independent endometrial transcriptomic dysregulation

ABSTRACT: We collected the eutopic endometrial biopsy from control women and women with endometriosis at both proliferative and secretory for RNA-seq analysis. We found regardless of endometriosis or not, the menstrual stage differences proliferative vs secretory accounts for the most changes of the transcriptome of all endometrial biopsy samples. Distinct and conserved gene expression patterns were induced by endometriosis at proliferative and secretory phases. From proliferative to secretory phase, endometriosis not only ablated the gene expression changes of some menstrual cycle dependent genes but also stimulated the menstrual cycle dependent expression changes in some new genes suggesting a dyssynchronous endometrium. Furthermore, we found eight endometriosis altered DEGs in our datasets are proximally localized to the endometriosis associated SNP at both proliferative and secretory phases. More interestingly, 75 published endometrial receptivity related genes were altered by endometriosis at secretory phase.

ORGANISM(S): Homo sapiens

PROVIDER: GSE272606 | GEO | 2024/12/31

REPOSITORIES: GEO

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