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Effect of autophagy inhibition (ATG7/13 KD) on the transcriptome of proliferating and senescent cells

ABSTRACT: To identify differentially expressed genes by autophagy inhibition during cellular senescence, we performed transcriptional profiling by RNA sequencing (RNA-seq) with or without autophagy inhibition (using a shRNA targeting either ATG7 or ATG13), before and after senescence induction using a stress-induced senescence model (bleomycin-induced senescence)

ORGANISM(S): Homo sapiens

PROVIDER: GSE272675 | GEO | 2024/10/02

REPOSITORIES: GEO

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