RNAseq analysis of blood from influenza infected patients and healthy controls, project SIG_combined, subset 1
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ABSTRACT: Study responses in peripheral blood of patients infected with influenza virus and compared to healthy control. Results: Strong differential host reponse after infection was observed.
Project description:Goals: Study responses in peripheral blood of patients infected with influenza virus and compare to healthy control. Results: Strong differential host reponse after infection was observed.
Project description:Gene expression changes in the blood was studied by RNAseq Results: Strong differential host reponse after infection with influenza virus compared to healthy controls project SIG_2020
Project description:Gene expression changes in the blood was studied by RNAseq; project SIG-2019 Results: Strong differential host reponse after infection with influenza virus compared to healthy controls
Project description:Gene expression changes in the blood was studied by RNAseq; project SIG-2018 Results: Strong differential host reponse after infection with influenza virus compared to healthy controls
Project description:The objective of this study was to understand the shared and unique elements of the host transcriptional response to different viral pathogens. We identified 162 subjects in the US and Sri Lanka with infections due to influenza, enterovirus/rhinovirus, human metapneumovirus, dengue virus, cytomegalovirus, Epstein Barr Virus, or adenovirus. Our dataset allowed us to identify common pathways at the molecular level as well as virus-specific differences in the host immune response. Conserved elements of the host response to these viral infections high-lighted the importance of interferon pathway activation. However, the magnitude of the re-sponses varied between pathogens. We also identified virus-specific responses to influenza, enterovirus/rhinovirus, and dengue infections.
Project description:Gene expression changes in the blood was studied by RNAseq Results: Highly damped host immune response in HIV patients after influenza infection