Low Vaccine Responder, Infection- and Asthma-prone Children Demonstrate Distinct Mononuclear Cell DNA methylation Pathways
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ABSTRACT: In this proof-of-concept study, we piloted a precision endotyping approach focused on DNA methylation biomarkers (CpG methylation) which are regulatory base modifications to DNA that influence cellular immune responses across the life course. The aims of this study were to (a) pilot a precision endotyping approach in a selected group of children from the Rochester prospective cohort who exhibited characteristics of high respiratory infection allergy/asthma prone (IAP) and low vaccine responsiveness (LVR) in early childhood, compared to non-respiratory infection allergy/asthma prone (NIAP) children and (b) assess whether stimulation of PBMCs with stimuli a vaccine adjuvant that activating activates a pattern recognition receptors (PRRs) could re-shape the epigenome.
ORGANISM(S): Homo sapiens
PROVIDER: GSE272991 | GEO | 2024/08/05
REPOSITORIES: GEO
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