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Ironomycin induces Mantle Cell Lymphoma cell death by targeting iron metabolism adicction

ABSTRACT: Mantle Cell lymphoma (MCL) remains an aggressive and incurable cancer with existing therapies, presenting a significant unmet clinical need. We evaluated the therapeutic interest of targeting iron homeostasis with Ironomycin alone and combined with ibrutinib, a BTK inhibitor accepted for the treatment of MCL patients. Patients commonly develop resistance to ibrutinib treatment. We found that ironomycin synergizes with ibrutinib to kill MCL cells even in ibrutinib-resistant cell lines.

ORGANISM(S): Homo sapiens

PROVIDER: GSE273121 | GEO | 2025/03/19

REPOSITORIES: GEO

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