Transcriptomics

Dataset Information

0

Nuclear EGFR in breast cancer suppresses NK cell recruitment and cytotoxicity


ABSTRACT: Natural Killer (NK) cells can target and destroy cancer cells, yet tumor microenvironments typically suppress NK cell recruitment and cytotoxicity. Recent work has demonstrated a novel role for nuclear EGFR (nEGFR) in regulating transcriptional events unique from the kinase domain. Using a novel peptide therapeutic (cSNX1.3) that inhibits retrograde trafficking of EGFR and an EGFR nuclear localization mutant, we discovered that nEGFR suppresses NK cell recruitment and cytotoxicity. RNA-seq analysis of breast cancer cells treated with cSNX1.3 or modified to lack a nuclear localization sequence (EGFRΔNLS) revealed the EGF-dependent induction of NK activating antigens, while kinase inhibition by erlotinib did not impact these genes. Together, the data demonstrate a unique immunomodulatory role for nEGFR.

ORGANISM(S): Homo sapiens

PROVIDER: GSE273890 | GEO | 2024/11/15

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
GSE273890_counts.txt.gz Txt
Items per page:
1 - 2 of 2

Similar Datasets

2012-05-29 | E-GEOD-38310 | biostudies-arrayexpress
2007-07-24 | E-TABM-239 | biostudies-arrayexpress
2012-05-30 | GSE38310 | GEO
2019-01-01 | GSE106151 | GEO
2016-10-07 | PXD002206 | Pride
2014-06-19 | GSE57422 | GEO
2014-10-07 | GSE62061 | GEO
2014-06-19 | E-GEOD-57422 | biostudies-arrayexpress
2012-08-16 | E-GEOD-40130 | biostudies-arrayexpress
2013-11-18 | E-GEOD-51880 | biostudies-arrayexpress