Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Beta,Beta-Dimethylacryloyl shikonin, mechanism of preventing and treating zebrafish soybean meal enteritis

ABSTRACT: The aim of this study is to explore through transcriptomics, β, β Dimethylacryloyl shikonin, mechanism for preventing and treating in zebrafish.

ORGANISM(S): Danio rerio

PROVIDER: GSE273916 | GEO | 2024/08/15

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

Expression profile of shikonin resistant K562 cell line

2011-12-10 | GSE34298 | GEO

Shikonin inhibit progression of colon cancer

Project description:To investigate the role of shikonin in the development of colon cancer, we treated HCT116 cells with shikonin for 24 hours We then used RNA-seq data from HCT116 cells for gene expression profiling

2024-09-13 | GSE234709 | GEO

Inhibitory effect of shikonin on lung cancer cells

Project description:To investigate the effect of shikonin on the proliferation and migration of lung cancer cells, we used shikonin treated with A549 and H1299 cells We then performed gene expression profiling using RNA-seq data from A549 cells.

2024-01-10 | GSE222640 | GEO

RNA-Seq analysis of breast cancer cells after shikonin treatment

Project description:We performed RNA-seq analysis using differnt breast cancer cell lines (MCF-7, SK-BR-3 and MDA-MB-231) after shikonin treatment. We reported that shikonin enhances the expression of DUSP-1 and DUSP-2. Shikonin induces apoptosis and decreases the phosphorylation of JNK1/2 through activationg DUSP-1 and DUSP2.

2018-02-13 | GSE100687 | GEO

Expression profile of shikonin resistant K562 cell line

Project description:After over 25cycle and 18month's induction of shikonin, K562 cell show maginal resistance to shikonin but great change in gene expression We use microarray to detect the global gene expression change of shikonin resistant cell K562 cell was treated by 4uM shikonin for 4hours, then allowed to die and grow back in fresh medium. Once recovered, cells were immidiatly subjected to another treatment.

2011-12-10 | E-GEOD-34298 | biostudies-arrayexpress

Effect of Shikonin on Aspergillus terreus

Project description:Aspergillus terreus is an emerging fungal pathogen in immunocompromised patients. Due to intrinsic resistance of AmB against A. terreus and acquiring resistance to azoles, alternative antifungal strategy needs investigation. Thus, we explored the activity of phytochemicals such as Shikonin, gallic acid, coumaric acid and quercetin against A. terreus. Amongst these, shikonin showed significant inhibition at MIC50;2 µg/ml, considered for proteome profiling.

2021-06-19 | PXD016797 | Pride

Effects of shikonin on the gene expression of human lymphoma U937 cells

2010-10-20 | GSE24743 | GEO

Effects of shikonin on the gene expression of human lymphoma U937 cells

Project description:Shikonin is a active component isolated from the roots of the traditional Chinese herb Lithospermum erythrorhizon and exhibits multiple pharmacological properties, such as anti-oxidant, anti-inflammatory, and anti-tumor effects. Here, the effects of shikonin on the gene expression of human lymphoma U937 cells were investigated using an Affymetrix GeneChip system. The cells were treated with 100 nM shikonin, and followed by incubation for 3h at 37Â°C. Flow cytometry analysis with Annexin-V and propidium iodide demonstrated that no cell death was observed in the cells at 100 nM shikonin. Of approximately 47,000 probe sets analyzed, many genes that were differentially expressed by a factor 2.0 or greater were identified in the cells treated with the compound. U937 cells, a human lymphoma cell line, were treated with 100 nM shikonin and followed by incubation for 3h at 37Â°C. The cells treated with dimethyl sulfoxide were served as control. Total RNA samples were prepared from the cells. Gene expression was analyzed by an Affymetrix GeneChipÂ® system with a Human Genome U133-plus 2.0 array for analysis of over 47,000 transcripts. Sample preparation for array hybridization was carried out as described in the manufacturerâs instructions.

2010-10-20 | E-GEOD-24743 | biostudies-arrayexpress

Transcriptome and microRNA array analyses reveal a stimulatory effect of the phytochemical shikonin on epithelial–mesenchymal transition (EMT) in mouse skin [microRNA expression profile]

Project description:We investigate and define here the in vivo biological effects of shikonin, at the transcriptome and microRNA levels, in mouse skin tissues. Through cross-examination between total RNA transcripts and microRNA data sets, we predicted that shikonin treatment may affect the epithelial–mesenchymal transition (EMT) process and the expression of related microRNAs, including 200a, 200b, 200c, 141, 205 and 429 microRNAs, in test skin tissue. Indeed, further in vivo tests on mouse abdominal skin tissue confirmed the stimulatory effect of shikonin on regulatory molecules of the EMT process in epidermal tissue. In addition, RT-PCR analyses confirmed the downregulating effects of shikonin on the expression of microRNA 205 and members of the microRNA 200 family, which are known to be involved in the EMT process. Gene expression of two RNA targets of the microRNA 200 family in EMT regulation, namely Sip1 (Zeb2) and Tcf8 (Zeb1), were consistently upregulated by shikonin treatment. We demonstrate here that shikonin can confer a potent stimulatory effect on the EMT process and suppress the associated-microRNAs expression in vivo in skin tissues.

2011-12-31 | GSE32695 | GEO

Transcriptome and microRNA array analyses reveal a stimulatory effect of the phytochemical shikonin on epithelial–mesenchymal transition (EMT) in mouse skin [gene expression profile]

2011-12-31 | GSE32694 | GEO