NLRP3 Amplifies Inflammatory Signaling in Acute Lung Injury Induced by Cell Wall Extract of Gram-positive Bacteria
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ABSTRACT: Transcriptomic analysis suggested that LCWE and LPS both induce Toll/NF-kB and TNF signalings in ALI, and LCWE additionally promotes T cell differentiation.We established a murine model of ALI-induced by LCWE. TLR2 receptors are activated by LCWE and transmitted through the MYD88 signaling pathway, activating NF-kappaB which leads to the production of IL1b and activation of TNFR and NLRP3 signaling pathways.
ORGANISM(S): Mus musculus
PROVIDER: GSE273921 | GEO | 2024/11/10
REPOSITORIES: GEO
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