The hepatic overexpression of C2-AKT ameliorates obesity-induced insulin resistance

ABSTRACT: Metabolic disorders, such as obesity and diabetes, have become increasingly prevalent worldwide, posing significant challenges to public health. Insulin resistance, a hallmark of these disorders, is characterized by an impaired response to insulin in target tissues, leading to dysregulated glucose and lipid metabolism. Although the pathogenesis of insulin resistance is complex and multifactorial, mounting evidence suggests that disrupted intracellular calcium (Ca2+) homeostasis plays a crucial role in its development. To elucidate the molecular mechanisms underlying the improved metabolic profiles in C2-AKT overexpression mice, we performed RNA-seq on liver tissues from both control and C2-AKT mice

ORGANISM(S): Mus musculus

PROVIDER: GSE274517 | GEO | 2024/08/26

REPOSITORIES: GEO