Transcriptomics

Dataset Information

0

Targeting NTRK1 Enhances Immune Checkpoint Inhibitor Efficacy in NTRK1 Wild-type Non-Small Cell Lung Cancer


ABSTRACT: Treatment of non-small cell lung cancer (NSCLC) has drastically changed in recent years owing to the robust anti-cancer effects of immune-checkpoint inhibitors (ICI). However, only 20% of NSCLC patients benefit from ICIs, highlighting the need to uncover the mechanisms mediating resistance. By analyzing the overall survival (OS) and mutational profiles of 424 NSCLC patients who received ICI treatments between 2015 and 2021, we determined that patients carrying a loss of function mutation in neurotrophic tyrosine kinase receptor 1 (NTRK1) had a prolonged OS compared to patients with wild-type NTRK1. Notably, suppression of the NTRK1 pathway by knockdown or Entrectinib treatment significantly enhanced ICI efficacy in mouse NSCLC models. RNA sequencing of tumors and NTRK1 knockdown cell lines were performed to demonstrates the role for NTRK1 signaling.

ORGANISM(S): Mus musculus

PROVIDER: GSE274960 | GEO | 2024/08/20

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2018-05-01 | GSE98642 | GEO
2021-07-31 | GSE180440 | GEO
2024-09-02 | GSE270047 | GEO
2023-07-11 | BIOMD0000001074 | BioModels
2020-11-01 | E-MTAB-8867 | biostudies-arrayexpress
2024-05-01 | GSE260770 | GEO
2021-11-11 | PXD026876 | Pride
2021-11-11 | PXD026913 | Pride
2023-03-22 | GSE221028 | GEO
2022-03-26 | GSE199245 | GEO