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Neurodevelopmental hijacking of oligodendrocyte lineage programs drives glioblastoma infiltration [scMultiome]

ABSTRACT: Glioblastoma cells infiltrate and incorporate into the normal brain parenchyma. We conduct unbiased multimodal single-cell and spatial sequencing to capture GBM cells and the surrounding tumor microenvironment using a regional sampling strategy. For each patient, we profile the peritumoral region, tumor edge, and tumor core, providing a comprehensive characterization of the transcriptional and epigenetic landscape of GBM spatial heterogeneity, with a specific focus on infiltrative cells.

ORGANISM(S): Homo sapiens

PROVIDER: GSE274986 | GEO | 2025/04/01

REPOSITORIES: GEO

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