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Integrated Profiling of Extracellular Vesicles microRNA Impact on Trabecular Meshwork mRNA Expression: Insights from Microarray Analysis

ABSTRACT: Oxidative stress in non-pigmented ciliary epithelial cells leads to secretion of extracellular vesicles containing microRNAs that alter gene expression in trabecular meshwork cells. This study identified differentially expressed miRNAs and genes, revealing potential mechanisms in primary open-angle glaucoma progression and suggesting new therapeutic targets. We used microarrays to detail the global programme of gene expression underlying cellularisation and identified distinct classes of up-regulated genes during this process.

ORGANISM(S): synthetic construct Homo sapiens

PROVIDER: GSE275895 | GEO | 2024/12/29

REPOSITORIES: GEO

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