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Transcriptome changes caused by PHF6 knockout in THP1 human AML cell line

ABSTRACT: CRISPR Cas9 guided knockout (KO) of PHF6 in human THP1 AML cell line. We performed bulk RNA-Seq on knockout (PHF6 KO) and wildtype (CTRL) clones derived from THP1 cells transduced with lentiviral vectors encoding Cas9 protein and either PHF6 gRNAs or non-targeting gRNAs. Our results reveal that PHF6 knockout upregulates self-renewal gene sets and downregulates myeloid differentiation gene sets.

ORGANISM(S): Homo sapiens

PROVIDER: GSE277149 | GEO | 2024/09/18

REPOSITORIES: GEO

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