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Transcriptional profiling of the flow-sorted mouse blood monocyte subsets

ABSTRACT: Classical monocytes (CMs) can be converted into conventional dominant Nr4a1-dependent nonclassical monocytes (N-NCMs). Upon activation of Nod2 signaling, CM also can be converted into noncanonical Nod2-dependent inducible NCMs (I-NCMs). The transcriptional profiles and typical markers specific for those two NCM subsets yet to be determined. To transcriptionally characterize N-NCM and I-NCM, we performed transcriptional profiling analysis using RNAseq data obtained from the flow-sorted NCM subsets. Through the comprehensive RNAseq analysis, we identified typical transcriptional markers specific to N-NCM and I-NCM. By virtue of those specific markers, we identified the potential I-NCM populations in multiple cellular settings.

ORGANISM(S): Mus musculus

PROVIDER: GSE277303 | GEO | 2024/11/15

REPOSITORIES: GEO

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			Action	DRS
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	GSE277303_Sample-B1-18-htseq.all.counts.txt.gz	Txt
	GSE277303_Sample-B2-1-htseq.all.counts.txt.gz	Txt
	GSE277303_Sample-B3-1-htseq.all.counts.txt.gz	Txt

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