Salmonella infection accelerates potential maturation of the intestinal epithelium

ABSTRACT: Postnatal establishment of enteric metabolic, host-microbial and immune homeostasis is the result of precisely timed and tightly regulated developmental and adaptive processes. Here, we show that infection with the invasive enteropathogen Salmonella Typhimurium results in a Myd88-dependent accelerated maturation of the neonatal epithelium with premature appearance of antimicrobial, metabolic, developmental, and regenerative features of the adult tissue.

ORGANISM(S): Mus musculus

PROVIDER: GSE278410 | GEO | 2024/12/17

REPOSITORIES: GEO