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Gene expression profile at single cell level of lung alveolar macrophages (AM) and interstital macrophages (IM) in MMTV-HER2 and wildtype early stage (16-week) or late stage (32-week) mice.

ABSTRACT: Disseminated cancer cells reside in the lung alveolar niche where they are exposed to interactions with alveolar macrophages. Here we report singe-cell RNA-sequencing data of lung macrophages from MMTV-HER2 mice at the early stage (16-weeks) harboring single dormant cancer cells and late stage mice (32-weeks harboring metastatic lesions, as well as wildtype control mice. We discovered alveolar macrophage and interstitial macrophage subsets that change in expression profile and frequency between stages. We find majority of the AMs are homeostatic in phenotype, and emergence of inflammatory AM subsets in late-stage MMTV-HER2 mice.

ORGANISM(S): Mus musculus

PROVIDER: GSE278454 | GEO | 2024/10/01

REPOSITORIES: GEO

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