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Non-classical action of Ku70 promotes Treg suppressive function through a FOXP3-dependent mechanism in lung adenocarcinoma

ABSTRACT: To explore the role of Ku70 in Treg cell biology, we isolated conventional T cells (Tconv) and regulatory T cells (Treg) from Foxp3Yfp-cre mice and performed Ku70 ChIP-seq. Furthermore, to investigate the impact of Ku70 deficiency on Foxp3 binding patterns, we sorted Treg cells from Foxp3Cre (WT) and Xrcc6fl/fl;Foxp3Cre (KO) mice and conducted Foxp3 ChIP-seq. These analyses revealed that Ku70 forms a complex with FOXP3, which supports FOXP3 transcriptional activity.

ORGANISM(S): Mus musculus

PROVIDER: GSE278950 | GEO | 2024/11/04

REPOSITORIES: GEO

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Effect of depletion of Ku70 on gene expression profiles of murine regulatory T cells in lung tumor microevnronment

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2013-08-18 | E-GEOD-47989 | biostudies-arrayexpress

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2012-04-26 | E-GEOD-37605 | biostudies-arrayexpress

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