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Impact of mitochondrial citrate carrier expression on metabolism in the developing heart

ABSTRACT: Slc25a1 encodes for the mitochondrial citrate carrier, a mitochondrial inner membrane transporter that mediates mitochondrial citrate export. Systemic deletion of Slc25a1 (both homozygous and heterozygous loss) leads to cardiac structural defects and mitochondrial dysfunction. Transcriptomic profiles of metabolic gene expression in the the developing mouse heart at E17.5 reveal alterations in metabolic pathways including oxdiative phosphorylation, supporting mitochondrial structural and functional defects observed with loss of this transporter.

ORGANISM(S): Mus musculus

PROVIDER: GSE279295 | GEO | 2024/10/11

REPOSITORIES: GEO

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