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Transcriptome in naturally-occuring self-reactive thymocytes

ABSTRACT: In the Nur77/Nr4a1-eGFP BAC Tg reporter mice, GFP expression positively correlates with TCR signaling strength. We postulate that among post-selection thymocytes, GFP expression reflects self-antigen recognition across the TCR repertoire. Here we identify differentially expressed transcripts in semimature SP4 thymocytes (CD25- CD69+ CD24+) from Nur77-eGFP BAC Tg reporter mice sorted on 10% highest, intermediate, and lowest GFP expression.

ORGANISM(S): Mus musculus

PROVIDER: GSE279344 | GEO | 2024/10/31

REPOSITORIES: GEO

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