Loss of ZEB2 in basal breast cancer cells
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ABSTRACT: Study of loss of ZEB2 in breast cancer cells in vitro and in vivo: gene expression and phenotypic switch to more benign behavior of the cancer cells. Morphological, functional and gene microarray analysis following ZEB2 knockdown in MDAMB231 cells reveals gain of epithelial differentiation, reduction of migration, invasion and metastatic capability. The measurement of ZEB2 transcriptional activity in tumor cells efficiently predicts the probability of breast cancer patient survival.
ORGANISM(S): Homo sapiens
PROVIDER: GSE27966 | GEO | 2016/03/15
SECONDARY ACCESSION(S): PRJNA137759
REPOSITORIES: GEO
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