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Single-cell RNA sequencing reveals T and B cell-related immune features in foot and mouth disease virus-infected mice

ABSTRACT: T and B lymphocytes protect against foot and mouth disease virus (FMDV). They are essential for long-term immunity and viral clearance, but their immunological features in FMDV infection remain unknown. Here, we performed single-cell RNA sequencing (scRNA-seq) and conducted integrative analyses to determine cell composition, gene expression, cell-cell communication state, and regulatory network of T and B cells in the spleen of FMDV- and mock-infected mice. Our results revealed variational compositions of immune cells on the subsets level. Additionally, we determined the reshaping of several important pathways in T and B cells, such as the inhibition of antigen-presentation capacity. Finally, the remolding of cell-cell communication and regulatory networks was also characterized during FMDV infection. Overall, our research provides valuable insights and abundant resources for understanding the adaptive immune response in FMD.

ORGANISM(S): Mus musculus

PROVIDER: GSE279768 | GEO | 2025/03/12

REPOSITORIES: GEO

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