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Study on the toxicity and action mechanism of diquat on Caenorhabditis elegans

ABSTRACT: Diquat (DQ), a contact herbicide extensively utilized in both agricultural and non-agricultural domains, exhibits a high correlation with neuronal disorders. Nevertheless, the toxicity and underlying mechanisms associated with exposure to environmental concentrations of DQ remain ambiguous. Here, we report a dose-dependent cellular neurotoxicity of DQ in C. elegans. Firstly, DQ significantly compromised the development and brood size of worms, shortened the lifespan, and caused epidermal abnormalities. An unbiased transcriptomic analysis disclosed several pathways related to cell death and peroxisome homeostasis underlying this organismal-level toxicity. Moreover, the exposure of DQ to C. elegans led to a notable increase of embryonic cell death. Concurrently, DQ exposure specifically caused the loss of dopamine neurons but not two types of neurons in adulthood, which is in accordance with DQ-induced muscle-related defects such as pharyngeal pumping, body bends, and head thrashes.

ORGANISM(S): Caenorhabditis elegans

PROVIDER: GSE280253 | GEO | 2025/01/20

REPOSITORIES: GEO

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Study on the toxicity and action mechanism of diquat on Caenorhabditis elegans

Project description:Study on the toxicity and action mechanism of diquat on Caenorhabditis elegans

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