Identification of B cell stimulation-specific A20-repressed genesets
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ABSTRACT: Loss of one copy of the negative feedback regulator A20 is implicated in the development of autoimmunity. In mouse models the B cell specific loss of A20 can induce autoimmune phenotypes. To identify genesets which are repressed by A20 in B cell, we stimulated A20-deficient and control B cells in vitro with αIgM, αCD40 or LPS for 3 or 14 hours to reflect B cell receptor engagement, T cell help and innate/TLR signals, respectively, and analyzed the effect on gene expression.
ORGANISM(S): Mus musculus
PROVIDER: GSE280298 | GEO | 2024/12/21
REPOSITORIES: GEO
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