Effect of MSMP inhibition on the gene expression profiles of rheumatoid fibroblast-like synoviocytes

ABSTRACT: To explore the downstream target of MSMP, RNA-sequencing (RNA-seq) was used to display gene expression profiles in fibroblast-like synoviocytes (FLSs) from 3 patients with rheumatoid arthritis (RA) between control siRNA (siC) group and siMSMP-2 group (with the highest interference efficiency for MSMP). The heatmap and volcano diagram showed a total of 216 differentially expressed genes with 77 upregulated genes and 139 downregulated genes (Fold change≥1.5，p<0.05)

ORGANISM(S): Homo sapiens

PROVIDER: GSE280445 | GEO | 2024/10/28

REPOSITORIES: GEO