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TREM2 expression delineates spatially restricted and ontogenically distinct hepatic macrophages populations required for tissue repair. [10 Visium Spatial Seq]

ABSTRACT: Analysis of single cell RNA-seq, CITE-seq data and bulk RNA-seq data on cells isolated from the livers of mice following PBS and APAP (paracetamol/acetaminophen) administration. Spatial Transcriptomics analysis was performed using 10x Visium platform on mouse livers 48hrs post PBS or APAP administration. We also analysed single cell RNA-seq data on CD64+F4/80+ macrophages isolated from the livers of Trem2 fl/fl mice and CD64CRE Trem2 fl/fl mice.

ORGANISM(S): Mus musculus

PROVIDER: GSE280515 | GEO | 2024/10/30

REPOSITORIES: GEO

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TREM2 expression delineates spatially restricted and ontogenically distinct hepatic macrophages populations required for tissue repair. [bulkRNA-seq]

Project description:Analysis of single cell RNA-seq, CITE-seq data and bulk RNA-seq data on cells isolated from the livers of mice following PBS and APAP (paracetamol/acetaminophen) administration. Spatial Transcriptomics analysis was performed using 10x Visium platform on mouse livers 48hrs post PBS or APAP administration. We also analysed single cell RNA-seq data on CD64+F4/80+ macrophages isolated from the livers of Trem2 fl/fl mice and CD64CRE Trem2 fl/fl mice.

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