Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

3D chromatin hubs as regulatory units of identity and survival in acute T-cell leukemia [scATAC-Seq]

ABSTRACT: Cancer progression is associated with genetic and epigenetic aberrations that affect chromatin 3D organization in the nucleus. Changes in loop extrusion or phase separation alter the relationships between enhancer and promoter elements, defining novel gene expression programs that are selected to promote growth and survival. Here, we provide an integrative approach based on chromatin conformation, accessibility and transcription, further validated by CRISPR interference screenings in order to identify chromatin topologies relevant to different subtypes of T-cell leukemia, namely T-ALL and ETP-ALL. By focusing on highly interconnected elements, we characterized 3D hubs as headquarters of leukemia progression and identity, demonstrating that oncogenes and disease markers are regulated by multiple cis-regulatory regions.

ORGANISM(S): Homo sapiens

PROVIDER: GSE280728 | GEO | 2024/11/04

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

3D chromatin hubs as regulatory units of identity and survival in acute T-cell leukemia [HiChIP]

Project description:Cancer progression is associated with genetic and epigenetic aberrations that affect chromatin 3D organization in the nucleus. Changes in loop extrusion or phase separation alter the relationships between enhancer and promoter elements, defining novel gene expression programs that are selected to promote growth and survival. Here, we provide an integrative approach based on chromatin conformation, accessibility and transcription, further validated by CRISPR interference screenings in order to identify chromatin topologies relevant to different subtypes of T-cell leukemia, namely T-ALL and ETP-ALL. By focusing on highly interconnected elements, we characterized 3D hubs as headquarters of leukemia progression and identity, demonstrating that oncogenes and disease markers are regulated by multiple cis-regulatory regions.

2024-11-04 | GSE280796 | GEO

3D chromatin hubs as regulatory units of identity and survival in acute T-cell leukemia [hiChIP]

2023-09-25 | GSE243913 | GEO

3D chromatin hubs as regulatory units of identity and survival in acute T-cell leukemia [etp82a_RNA-seq]

2024-11-04 | GSE280798 | GEO

3D chromatin hubs as regulatory units of identity and survival in acute T-cell leukemia [RNA-seq]

2023-09-25 | GSE243914 | GEO

3D chromatin hubs as regulatory units of identity and survival in acute T-cell leukemia.

Project description:3D chromatin hubs as regulatory units of identity and survival in acute T-cell leukemia.

| PRJNA1020562 | ENA

Transcriptional circuits that regulate early T cell precursor acute leukemia [HiChIP]

Project description:The discovery of early T-cell precursor acute lymphoblastic leukemia (ETP-ALL) was based on expression of stem cell genes that are characteristic of mouse ETP cells, the most primitive multipotent cells in the thymus. Using complementary mouse and human genetic models and genome-wide expression and chromatin profiling integrated with 3D chromatin mapping, we show that the PIAS-like coactivator ZMIZ1 promotes immature T-ALL proliferation by recruiting the transcription factor MYB in feedforward circuits to cooperatively induce MYCN, MEF2C, and BCL2, which were recently associated with the high-risk bone marrow progenitor (BMP-like) subset.

2023-07-03 | GSE235847 | GEO

Transcriptional circuits that regulate early T cell precursor acute leukemia [Hi-C]

2023-07-03 | GSE235846 | GEO

Transcriptional circuits that regulate early T cell precursor acute leukemia (RNA-seq)

2023-07-05 | GSE235685 | GEO

3D chromatin hubs as regulatory units of identity and survival in acute T-cell leukemia [hiChIP]

Project description:3D chromatin hubs as regulatory units of identity and survival in acute T-cell leukemia [hiChIP]

| PRJNA1020565 | ENA

3D chromatin hubs as regulatory units of identity and survival in acute T-cell leukemia [HiChIP]

Project description:3D chromatin hubs as regulatory units of identity and survival in acute T-cell leukemia [HiChIP]

| PRJNA1180548 | ENA